Leon C. Moore, Ph.D.

Professor of Physiology & Biophysics

Ph.D., Biomedical Engineering

University of Southern California, 1976.

Tel: 631 444 3407

Fax: 631 444 3432

Research Projects:

The Mechanism of Tear Secretion by the Lacrimal Glands

The goal of this project is to define the mechanism of ion and water transport in acinar cells in lacrimal gland. We conduct studies in mice and in isolated cells to determine the effects of ion transport inhibitors on tear fluid secretion. Using these data, we are constructed mathematical models of acinar and duct cell ion transport. These studies are important in understanding dry-eye disease.

Nonlinear Dynamics of the Renal Tubuloglomerular Feedback System

Tubuloglomerular feedback (TGF) regulates renal hemodynamics and sodium excretion. The research goal is to elucidate the function of the TGF system in healthy and hypertensive rats. Experimental studies are done to assess the regulation of cortical blood flow and to estimate TGF system parameters using time-varying spectral analysis and mathematical models. Models of epithelial ion transport are also used to study TGF signal generation in the thick ascending limb of Henle’s loop (TAL).

Collaborators:

At Stony Brook: Chris Clausen, Ki Chon, Peter Brink

At Duke University: Harold Layton, Anita Layton

At Soonchunhyang University, Korea: Hun Mo Yang

At IURC, Montpellier, France: Daniel Casellas

Representative publications:

Walcott B, Birzgalis A, Moore LC, and Brink PR. Fluid secretion and the Na⁺, K⁺, 2Cl^- cotransporter (NKCC1) in mouse exorbital lacrimal gland. Am J Physiol Cell Physiol, 289: C860-897, 2005.

Layton AT, Moore LC, and Layton HE. Multistability in tubuloglomerular feedback and spectral complexity in spontaneously hypertensive rats. Am J Physiol Renal Physiol, 291: F79–F97, 2006.

Marcano, M., H.-M. Yang, A. Nieves-Gonzalez, C. Clausen, and L.C. Moore. Parameter estimation for models of NKCC2 cotransporter isoforms. Am J Physiol Renal Physiol 296:F369-81, 2009.