Chris Clausen, Ph.D.

Department of Physiology and Biophysics

Ion transport mechanisms in epithelia: regulation of proton transport in renal epithelia, the role of endo- and exocytotic processes in altering rates of ion transport, and mechanisms involved in epithelial sodium, chloride and glucose transport. Experimental techniques include analysis of epithelial electrical impedance, transepithelial and intracellular electrophysiological recordings, measurements of uptake and release of fluid-phase makers, fluorescence microscopy, whole-cell patch-clamp studies, morphometric analyses, and computer modeling. Mathematical modeling of the electrical activity in the heart: computer models of ionic currents in Purkinje fibers and ventricular myocytes, computation of space-clamped and propagating action potentials, investigation of antiarrhythmic drug actions, and modeling of arrhythmias, notably early after depolarizations and reentrant arrhythmias.

Weinstein, S.W & Clausen, C. Adaptive responses to Na+- coupled solute transport and osmotic cell swelling in salamander proximal tubule. American Journal of Physiology 267:F479-488, 1994.

Wills, N.K., Purcell, R.K., Clausen, C. & Millinoff, L.P. Effects of aldosterone on the impedance properties of cultured renal amphibian epithelia. Journal of Membrane Biology 133:17-27, 1993

Rich, A., Dixon, T.E. & Clausen, C. Electrogenic bicarbonate secretion in the turtle bladder: apical membrane conductance characteristics. Journal of Membrane Biology 119: 241-252, 1991

Last updated 1/14/00