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RECENT PUBLICATIONS |
Shoshani, I., Taussig, R., Iyengar, I., and Johnson, R.A. (2000) Synthesis and use of 3'-(azidoiodosalicyl)-derivatives of 2',5'-dideoxyadenosine as photoaffinity ligands for adenylyl cyclase. Arch. Biochem. Biophys. 374: (March, In Press).
Shoshani, I., Bianchi, G., Désaubry, L., Dessauer, C.W., and Johnson, R.A. (2000) Lys-Ala mutations of type I
adenylyl cyclase result in altered susceptibility to inhibition by adenine nucleoside 3'-polyphosphates.
Arch Biochem.
Biophys.
374: 389-394.
Shoshani, I., Boudou, V., Pierra, C.,
Gosselin, G., and Johnson, R.A. (1999) Enzymatic synthesis of unlabeled and [b-32P]-labeled
b-L-2',3'-dideoxyadenosine-5'-triphosphate as a potent inhibitor of adenylyl cyclases and its use as
reversible binding ligand. J. Biol. Chem.
274: 34735-34741.
Shoshani, I., Laux, W.H.G., Périgaud, C., Gosselin, G., and Johnson, R.A. (1999) Inhibition of adenylyl cyclase by
acyclic nucleoside phosphonate anti-viral agents.
J. Biol. Chem. 274:
34742-34744 .
Doronin, S., Murray, L., Dessauer, C.W., and Johnson,
R.A. (1999) Covalent labeling of adenylyl cyclase cytosolic
domains with 2',5'-dideoxy-[g-32P]-3'-ATP and the mechanism for P-site-mediated inhibition. J. Biol. Chem. 274:
34745-34750 .
Tesmer, J.J.G., Sunahara, R.K., Johnson, R.A., Gosselin, G., Gilman, A.G., and Sprang, S.R. (1999) Two metal ion
catalysis in adenylyl cyclase revealed by its complexes with ATP analogs, Mg2+, Mn2+, and Zn2+. Science 285:
756-760.
Ibrahimi, A., Abumrad, N., Maghareie, H., Golia, M., Shoshani, I., Désaubry, L., and Johnson, R.A. (1999) Adenylyl
cyclase P-site inhibitors accelerated differentiation in Ob-1771 preadipocytes.
Am J.
Physiol. 276
(Cell Physiol. 45):
C487-C496.
Szczepanik, M., Désaubry, L., and Johnson, R.A. (1998) One-pot synthesis of deoxy-adenosine 3'-thiophosphates.
Tetrahedron
Lett. 39: 7455-7458.
Doronin, S., Dessauer, C., and Johnson, R.A. (1998) Direct photoaffinity labeling of individual cytosolic domains of
adenylyl cyclase by [32P]-2'-d-3'AMP and
[a-32P]-5'ATP. J. Biol. Chem. 273: 32416-32420 .
Désaubry, L., and Johnson, R.A. (1998) Adenine nucleoside-3'-tetraphosphates are novel and potent inhibitors of
adenylyl cyclases.
J. Biol. Chem. 273: 24972-24977 .
Johnson, R.A., Désaubry, L., Bianchi, G.,, Shoshani, I., Lyons, E., Jr., Taussig, R., Watson, P.A., Cali, J.J., Krupinski,
J., Pieroni, J.P., and Iyengar, R. (1997) Isozyme-dependent sensitivity of adenylyl cyclases to P-site-mediated
inhibition by adenine nucleosides and nucleoside-3'-polyphosphates. J. Biol. Chem. 272: 8962-8966.
Désaubry, L., Shoshani, I., and Johnson, R.A. (1996) Inhibition of adenylyl cyclase by a family of newly synthesized
adenine nucleoside 3'-polyphosphates suggests new regulatory pathways. J. Biol. Chem. 271: 14028-14034.
Désaubry, L.,
Shoshani, I., and Johnson, R.A. (1996)
2',5'-dideoxyadenosine-3'-polyphosphates are potent
inhibitors of adenylyl cyclases. J. Biol. Chem. 271: 2380-2383.
Désaubry, L., and Johnson, R.A. (1996) Conjugation of nucleoside triphosphates to an amino linker.
Bioorg. & Med.
Chem. Lett. 7: 123-126.
Theil,
F., Ballschuh, Sibylle, von Janta-Lipinski, M., and Johnson, R.A. (1996)
Chemoenzymatic synthesis of carbocyclic nucleoside analogues with
bicyclo[3.1.0]hexyl residues. J. Chem. Soc., Perkin Trans. 1:
255-258.
Désaubry, L., , Shoshani, I., and Johnson, R.A. (1995) Synthesis of
2'-deoxy- and 2',5'-dideoxy-adenosine-3'-di- and -3'-triphosphate. Tetrahedron
Lett. 36: 995-996.
Désaubry, L., Shoshani, I., and Johnson, R.A. (1995) Synthesis of
2',5'-dideoxyadenosine-3'-monophosphate derivatives as allosteric inhibitors
of adenylyl cyclase. Nucleosides and Nucleotides 14: 1453-1460.
Shoshani, I., Qui, H., Johnson, F., Taussig, R., and Johnson, R.A. (1995)
Azido-iodo-phenyl- analogs of 2',5'-dideoxyadenosine as affinity ligands for
adenylyl cyclase. Biochim. Biophys. Acta 1245: 37-42.
Shoshani, I., Qiu, H., Johnson, F., and Johnson,
R.A. (1994) Synthesis of
iodo-aryl-azido adenosine analogs as affinity ligands for adenylyl cyclase. Nucleosides
and Nucleotides 13: 1977-1989.
Bushfield, M., Shoshani, I., and Johnson, R.A. (1990) Tissue levels,
source, and regulation of 3'AMP: An intracellular inhibitor of adenylyl
cyclase. Molec. Pharmacol. 38: 848-853.
Johnson, R.A., and Shoshani, I. (1990) Inhibition of Bordetella pertussis
and Bacillus anthracis adenylyl cyclases by polyadenylate and
"P"-site agonists. J. Biol. Chem. 265: 19035-19039.
Yeung, S.-M.H., and Johnson, R.A. (1990) Irreversible inactivation of
adenylate cyclase by the P-site agonist
2',5'-dideoxy-3'-p-fluorosulfonyl-benzoyl-adenosine. J. Biol. Chem. 265:
16745-16750.
Johnson, R.A., and Shoshani, I. (1990) Kinetics of
"P"-site-mediated inhibition of adenylyl cyclase and the
requirements for substrate. J. Biol. Chem. 265: 11595-11600.
Johnson, R.A., Yeung, S.M.H., Stübner, D., Bushfield, M., and Shoshani, I.
(1989) Cation and structural requirements for "P"-site-mediated
inhibition of adenylate cyclase. Molec. Pharmacol. 35: 681-688.