BIO 132 – Anatomy and Physiology II

LECTURE 20: PHYSIOLOGY OF THE URINARY SYSTEM I: GLOMERULAR FILTRATION

Study Outline

20.1. Overview of Renal Physiology:

a. glomerular filtration; tubular reabsorption; tubular secretion

b. glomerular filtration; the space of Bowman’s capsule (=capsular space)

c. peritubular capillaries; vasa recta; tubular reabsorption

d. tubular secretion

e. filtration; reabsorption; secretion

20.2. Glomerular Filtration:

a. being more permeable; hydrostatic pressures

b. size; charge

c. equal; proteins

20.3. Net Filtration Pressure:

a. Starling; capsular oncotic pressure

b. high; 55 mmHg; 35 mmHg

c. capsular space; capsular hydrostatic pressure; 15 mmHg

d. capillary oncotic pressure

e. factors that promote filtration; factors that oppose filtration; GHP; CHP; COP; 10 mmHg

20.4. Glomerular Filtration Rate:

a. 180; 125 mL/min

b. too fast; lost in urine; reabsorbed; retained

c. the surface area for filtration; the filtration permeability; net filtration pressure; increase; decrease

20.5. Regulation of GFR:

a. renal autoregulation; neural regulation; hormonal regulation

b. renal autoregulation; the myogenic mechanism; tubuloglomerular feedback

c. constrict; decrease; relaxation; increases

d. constriction; macula densa; vasoconstrictory

e. neural; hormonal

f. remains unchanged; relatively more; decreases

g. renin

h. angiotensin II; ANP; constrict; decrease; increase; mesangial